Antoine Lesur














Head of Proteomics Platform

Quantitative Biology Unit (QBU)

+352 26 970 935

ResearchGate | PubMed | Google Scholar

Research experience

2019 - present: Head of the proteomics platform

Luxembourg Institute of Health

2016 - present: Research staff

Luxembourg Institute of Health

2013 - 2016: Post Doctoral fellowship

Luxembourg Clinical proteomics unit

2007 - 2012: PhD

Life Science Mass Spectrometry Unit
University of Geneva

2006-2007 Engineer

Bordeaux proteomics core facility, France

2003 - 2006: Master in biotechnology

ENSTBB (National Superior School of Technologies of Biomolecules of Bordeaux), University of Bordeaux 2, France



• The clinical potential of prm-PASEF mass spectrometry. Expert Review of Proteomics 2021, 1-8
Lesur, A.; Dittmar, G.

• Highly Multiplexed Targeted Proteomics Acquisition on a TIMS-QTOF. Analytical Chemistry 2021, 93 (3), 1383-1392
Lesur, A.;  Schmit, P. O.;  Bernardin, F.;  Letellier, E.;  Brehmer, S.;  Decker, J.; Dittmar, G.

• Identification of a Blood-Based Protein Biomarker Panel for Lung Cancer Detection.Cancers 2020, 12(6), 1629
Victoria El-Khoury, Anna Schritz, Sang-Yoon Kim, Antoine Lesur, Katriina Sertamo, François Bernardin, Konstantinos Petritis, Patrick Pirrotte, Cheryl Selinsky, Jeffrey R. Whiteaker, Haizhen Zhang, Jacob J. Kennedy, Chenwei Lin, Lik Wee Lee, Ping Yan, Nhan L. Tran, Landon J. Inge, Khaled Chalabi, Georges Decker, Rolf Bjerkvig, Amanda G. Paulovich, Guy Berchem, and Yeoun Jin Kim

• Shedding Light on the Venom Proteomes of the Allergy-Relevant Hymenoptera Polistes dominula (European Paper Wasp) and Vespula spp. (Yellow Jacket). Toxins 2020, 12, 323.
Grosch, J.; Hilger, C.; Bilò, M.B.; Kler, S.; Schiener, M.; Dittmar, G.; Bernardin, F.; Lesur, A.; Ollert, M.; Schmidt-Weber, C.B.; Blank, S.

• Targeted proteomics identifies proteomic signatures in liquid-biopsies of the endometrium to diagnose endometrial cancer and assist in the prediction of the optimal surgical treatment. ClinicalCancer Research 2017 - PubMed
Martinez-Garcia, E.; Lesur, A.; Devis, L.; Cabrera, S.; Matias-Guiu, X.; Hirschfeld, M.; Asberger, J.; van Oostrum, J.; María de los Ángeles Casares de Cal, MA.; Gómez-Tato, A.; Reventos, J.; Domon, B.; Colas, E.; Gil-Moreno, A.

• Development of a sequential workflow based on LC-PRM for the verification of endometrial cancer protein biomarkers in uterine aspirate samples. Oncotarget 2016, 7, (33), 53102-53115 - PubMed
Martinez-Garcia, E.; Lesur, A.; Devis, L.; Campos, A.; Cabrera, S.; van Oostrum, J.; Matias-Guiu, X.; Gil-Moreno, A.; Reventos, J.; Colas, E.; Domon, B.

• Hyphenation of fast liquid chromatography with high-resolution mass spectrometry for quantitative proteomics analyses. TrAC Trends in Analytical Chemistry 2016 DOI
Lesur, A.; Gallien, S.; Domon, B.

• The use of proteases complementary to trypsin to probe isoforms and modifications. Proteomics 2016, 16, (5), 715-28. - PubMed
Trevisiol, S.; Ayoub, D.; Lesur, A.; Ancheva, L.; Gallien, S.; Domon, B.

• Structural characterization and biological implications of sulfated N-glycans in a serine protease from the neotropical moth Hylesia metabus (Cramer [1775]) (Lepidoptera: Saturniidae). Glycobiology 2016, 26, (3), 230-50. - PubMed
Cabrera, G.; Salazar, V.; Montesino, R.; Tambara, Y.; Struwe, W. B.; Leon, E.; Harvey, D. J.; Lesur, A.; Rincon, M.; Domon, B.; Mendez, M.; Portela, M.; Gonzalez-Hernandez, A.; Triguero, A.; Duran, R.; Lundberg, U.; Vonasek, E.; Gonzalez, L. J.

• Screening protein isoforms predictive for cancer using immunoaffinity capture and fast LC-MS in PRM mode. PROTEOMICS – Clinical Applications 2015 - PubMed
Lesur, A.; Ancheva, L.; Kim Y. J.; Berchem, G.; van Oostrum, J.; Domon, B.

• Advances in High-resolution accurate mass spectrometry application to targeted proteomics. Proteomics 2014 - PubMed
Lesur, A.; Domon, B.

• Quantification in MALDI-MS imaging: what can we learn from MALDI-selected reaction monitoring and what can we expect for imaging? Analytical and bioanalytical chemistry 2014. - PubMed
Porta, T.; Lesur, A.; Varesio, E.; Hopfgartner, G.

• Analysis of biopharmaceutical proteins in biological matrices by LC-MS/MS II. LC-MS/MS analysis. TrAC - Trends in Analytical Chemistry 2013, 48, 52-61. - DOI
Hopfgartner, G.; Lesur, A.; Varesio, E.

• Peptides Quantification by Liquid Chromatography with Matrix-Assisted Laser Desorption/Ionization and Selected Reaction Monitoring Detection. Journal of Proteome Research 2012, 11,(10),4972-82. - DOI
Lesur, A.; Varesio, E.; Domon, B.; Hopfgartner, G.

• Protein quantification by MALDI-selected reaction monitoring mass spectrometry using sulfonate derivatized peptides. Analytical Chemistry 2010, 82, (12), 5227-37. - PubMed
Lesur, A.; Varesio, E.; Hopfgartner, G.

• Accelerated tryptic digestion for the analysis of biopharmaceutical monoclonal antibodies in plasma by liquid chromatography with tandem mass spectrometric detection. Journal of Chromatography A 2010, 1217, (1), 57-64. - PubMed
Lesur, A.; Varesio, E.; Hopfgartner, G.


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