Collaboration with Dr. Annette KUEHN from Molecular and Translational Allergology unit of DII department.
Food allergy emerged over the past decade as an important public health problem, in a second wave of the 'allergy epidemic' succeeding the first respiratory epidemic. Clinical phenotypes of food-allergic patients are highly diverse - with allergen threshold doses varying from low to high, cross-reactions from limited to broad and symptoms from mild to severe. The current understanding of food allergy genesis has still many gaps. It remains elusive why individuals maintain a tolerogenic state to food allergens but others become allergic, experiencing local or systemic inflammatory responses. In this study, food-allergic patients as well as healthy controls will undergo food challenges with common allergenic foods (clinical partners). We analyze clinical samples from those study participants by mass spectrometry and single mass cytometry in order to conclude on clinical pheno- and endotypes of food-allergic patients. This will allow us develop new perspectives in terms of diagnosis and personalized treatment of diseased patients.
Project funding: FNR Luxembourg, Personalized Medicine Consortium